Debut de diabetes tipo 1 en niños durante la pandemia Covid-19 en el Hospital de Pediatría Juan P. Garrahan / Debut of type-1 diabetes in children during the COVID-19 pandemic at Hospital de Pediatría Juan P. Garrahan

Introducción: Según numerosos reportes, la pandemia por COVID­19 aumentó la incidencia de diabetes tipo 1 (DBT1) y cetoacidosis (CAD). Nuestro objetivo fue describir la frecuencia de nuevos casos de DBT1 y su severidad al ingreso en el Hospital J. P. Garrahan durante la pandemia, comparando con el periodo anterior. Material y métodos: Se realizó un estudio descriptivo, observacional, con análisis retrospectivo. Se incluyeron todos los nuevos casos entre 19/03/20- 31/12/21, comparados con el período 19/03/18-31/12/19. El diagnóstico de DBT1, CAD y su severidad se realizó según la International Society for Pediatric and Adolescent Diabetes. Se analizó el requerimiento de cuidados intensivos (UCI), presencia de COVID-19, hemoglobina glicosilada A1C (HbA1C) y autoanticuerpos (GADA, IAA, IA2, ZNT8). Se consideró significativa una p < 0,05. Resultados: En el período 2020-2021 se observó un incremento del 107% de nuevos casos, ingresando 56 pacientes con DBT1. La media y mediana de edad disminuyeron (8 vs 9,1 y 7,7 vs 10,4, respectivamente), con un incremento del 35% de menores de 5 años. Aumentó la frecuencia de CAD severa (41.1% vs 25.9%) y de requerimiento de UCI (17.9% vs 11.1%). La Hb A1C y la glucemia de ingreso mostraron incremento significativo (10.1% vs 12.32%, p<0.003 y 580 mg/dl ± 220 vs 490 mg/dl ± 188; p<0.05, respectivamente). Conclusión: En 2020-2021 se incrementó el número de nuevos casos de DBT1 en nuestra institución. Al ingreso hubo mayor proporción de niños pequeños y casos severos. Las dificultades de acceso a la consulta de atención primaria podrían relacionarse con nuestro hallazgo (AU)

Introduction: Numerous reports have shown that during the COVID-19 pandemic the incidence of type-1 diabetes (T1DB) and ketoacidosis (DKA) increased. The aim of this study was to describe the frequency of new cases and their severity on admission of T1DB at Hospital J. P. Garrahan during the pandemic, compared with the previous period. Material and methods: A descriptive, observational study with a retrospective analysis was conducted. All new cases seen between 19/03/20-31/12/21 were included and compared with the period 19/03/18-31/12/19. The diagnosis of T1DB, DKA, and its severity was made according to the International Society for Pediatric and Adolescent Diabetes. Intensive care (ICU) requirement, presence of COVID-19, glycosylated hemoglobin A1C (HbA1C), and autoantibodies (GADA, IAA, IA2, ZNT8) were analyzed. A p < 0.05 was considered significant. Results: In the period 2020-2021, a 107% increase in new cases was observed including 56 patients with T1DB. Mean and median age decreased (8 vs 9.1 and 7.7 vs 10.4, respectively), with a 35% increase in children under 5 years of age. The frequency of severe DKA (41.1% vs 25.9%) and ICU requirement (17.9% vs 11.1%) increased. Hb A1C and glycemia on admission also showed a significant increase (10.1% vs 12.32%, p<0.003 and 580 mg/dl ± 220 vs 490 mg/dl ± 188; p<0.05, respectively). Conclusion: In 2020-2021 an increase in the number of new cases of T1DB was observed at our institution. On admission, a higher rate of young children and severe cases was found. Difficulties to access primary care may have been related to our finding (AU)

Autoanticuerpos anti-insulina en la diabetes tipo 1 / Anti-insulin autoantibodies in type 1 diabetes

Introducción: Los autoanticuerpos anti-insulina (AAI) representan un marcador serológico de la diabetes tipo 1 (DT1). El significado clínico de los AAI aún no ha sido determinado en la población cubana. Objetivo: Determinar el valor clínico de AAI en pacientes con DT1. Métodos: Se determinaron los niveles séricos de AAI por el ensayo inmuno-adsorbente ligado a enzima (ELISA) en 33 pacientes adultos con DT1, 78 pacientes con otras condiciones endocrinas (CEE) como diabetes tipo 2, tiroiditis de Hashimoto e hiperinsulinemia, y 49 controles normales (CN). El valor de corte se determinó con el análisis de las curvas características operativas del receptor (COR) (ROC por sus siglas en inglés). Se utilizaron pruebas no paramétricas para comparar los niveles de AAI de pacientes con DT1, CEE y CN, y determinar la correlación entre AAI y la edad. Resultados: El valor de corte óptimo de AAI para DT1 fue el índice de 1,05, con sensibilidad de 45,5 por ciento, especificidad de 81,6 por ciento, razón de verosimilitud positiva de 2,47, y razón de verosimilitud negativa de 0,67. Los niveles de AAI en DT1 (índice de 0,97) fueron significativo, más altos que los de CN (índice de 0,70; p=0,020) y los de CEE (índice de 0,63; p= 0,009). Los niveles de AAI resultaron inversamente proporcionales a la edad en pacientes diabéticos ( =-0,252; p=0,030). Conclusiones: Los pacientes con DT1 se distinguieron por niveles más altos de AAI, aunque la presencia de estos anticuerpos no fue exclusiva de DT1. Los niveles de AAI dependieron de la edad en los pacientes diabéticos(AU)

Introduction: Anti-insulin autoantibodies (AAI) represent a serological marker of type 1 diabetes (T1D). The clinical significance of AAIs has not yet been determined in the Cuban population. Objective: To determine the clinical value of AAI in patients with T1D. Methods: AAI serum levels were determined by enzyme-linked immunosorbent assay (ELISA) in 33 adult patients with T1D, 78 patients with other endocrine conditions (CEE) such as type 2 diabetes, Hashimoto's thyroiditis, and hyperinsulinemia, and 49 normal controls (CN). The cut-off value was determined by receiver operating characteristic (ROC) curve analysis. Nonparametric tests were used to compare the AAI levels of patients with T1D, CEE, and CN, and to determine the correlation between AAI and age. Results: AAI optimal cut-off value for T1D was the index of 1.05, with 45.5 percent of sensitivity, 81.6 percent specificity, 2.47 positive likelihood ratio, and 0.67 negative likelihood ratio. AAI levels in DT1 (index of 0.97) were significant, higher than those of CN (index of 0.70; p= 0.020) and CEE levels (index of 0.63; p= 0.009). AAI levels were inversely proportional to age in diabetic patients (ρ = -0.252; p=0.030). Conclusions: Patients with T1D were distinguished by AAI higher levels, although the presence of these antibodies was not exclusive to T1D. AAI levels depended on age in diabetic patients(AU)

Evolucion del control metabolico en niños y adolescentes con diabetes tipo 1, luego del aislamiento implementado durante la pandemia por Covid-19 / Evolution of metabolic control in children and adolescents with tipe 1 diabetes, isolation implemented during the covid-19 pandemic

Introducción: la cuarentena adoptada durante la pandemia por COVID-19 significó grandes cambios en el cuidado de los pacientes con diabetes, pudiendo afectar el control metabólico. Objetivos: evaluar si existieron modificaciones en el control metabólico en menores de 18 años con diabetes tipo 1, seguidos en el Servicio de Nutrición y Diabetes del Hospital General de Niños Pedro de Elizalde (HGNPE), luego de las medidas de aislamiento social implementadas durante la pandemia por COVID-19. Estimar la frecuencia de complicaciones agudas y la variación del puntaje Z de Índice de masa corporal (IMC). Materiales y métodos: estudio observacional, longitudinal, retrospectivo. Se incluyeron pacientes de 1 a 18 años con diabetes tipo 1 de más de un año de evolución, con seguimiento regular en el HGNPE, que hayan sido evaluados, con determinación de hemoglobina glicosilada, entre diciembre de 2019 y marzo de 2020 (precuarentena). De estos pacientes, aquellos que asistieron a un control posterior, entre diciembre de 2020 y marzo de 2021, fueron considerados para un análisis comparativo. Resultados: se incluyeron 88 pacientes, de los cuales 59 se realizaron un control en el segundo período. La HbA1c inicial fue de 8,8% (IIC 25-75= 7,42-9,4) y la posterior de 8,3% (IIC 25-75= 7,2-9,95), el puntaje z de IMC inicial fue de 0,35 ± 1,02 y el posterior de 0,37 ± 0,97, siendo en ambos casos diferencias no significativas. Presentó complicaciones agudas el 15% (n= 9) de los pacientes. Conclusión: no se encontraron cambios significativos de la HbA1c y del puntaje z de IMC entre los períodos comparados

Introduction: the lock down during the COVID-19 pandemic meant great changes in the care of patients with diabetes, which could affect metabolic control. Objectives: to assesse whether there were changes in metabolic control in children under 18 years of age with type 1 diabetes followed up in the Nutrition and Diabetes Service of the Pedro de Elizalde Children's General Hospital (HGNPE), after the social isolation measures implemented during the COVID-19 pandemic and estimate the frequency of acute complications and the variation of the Z-score of Body Mass Index (BMI). Materials and methods: longitudinal, retrospective, observational study. Patients aged 1 to 18 years old with type 1 diabetes of more than one year of evolution, with regular follow-up in the HGNPE, who had been evaluated, with determination of glycosylated hemoglobin, between December 2019 and March 2020 (pre-quarantine) and between December 2020 and March2021. Of these patients, those who attended a subsequent control between December 2020 and March 2021 were considered for a comparative analysis. Results: 88 patients were included, of which 59 underwent a control in the second period. The initial HbA1c was 8,8% (IIC 25-75 = 7,42-9,4) and the subsequent one was 8,3% (IIC 25-75 = 7,2-9,95), the z-score of initial BMI was 0,35 ± 1,02 and the subsequent one was 0,37 ± 0,97, with non-significant differences in both cases. 15% (n = 9) of the patients had acute complications. Conclusion: no significant changes were found in HbA1c and BMI z-score between the periods compared

Vitamina D, miR-21 y marcadores de apoptosis en pacientes con diabetes tipo I / Vitamin D, miR-21 and apoptosis markers in patients with type 1 diabetes

La diabetes Tipo 1 (DT1) es una compleja enfermedad autoinmune con una etiología aún desconocida. La vitamina D ha sido ampliamente estudiada debido a su potencial terapéutico en los potenciales nuevos casos de DT1. Por otra parte, los microARNs (miRs) han sido propuestos como posibles biomarcadores en diversos procesos biológicos como en la apoptosis e inflamación. El objetivo de este estudio fue evaluar el efecto de la suplementación con vitamina D sobre el perfil de expresión del miR-21 y marcadores de apoptosis tales como: BCL2, STAT3, TIPE2 y DAXX, en células mononucleares periféricas provenientes de pacientes con DT1 y sujetos controles. RESULTADOS: El perfil de expresión de miR-21 se encontró disminuido en los pacientes con DT1 en comparación con los controles. La expresión relativa de BCL2 se encontró aumentada en controles al comparar con pacientes DT1 en todas las condiciones experimentales. La expresión relativa de DAXX mostró un perfil de expresión diferencial al comparar pacientes con DT1 versus controles (p=0.006). CONCLUSIÓN: El estímulo con vitamina D parece tener un posible efecto regulador sobre los genes BCL2 y DAXX.

Type 1 diabetes (T1D) is a complex chronic autoimmune disease. Vitamin D has been one of the most studied therapeutic potential outbreaks related to T1D. Specific miRNAs have been proposed as potential biomarkers in several biological processes as apoptosis and inflammation. The aim of this study was to evaluate the effect of vitamin D on the expression profiles of miR-21 and apoptotic markers BCL2, STAT3, TIPE2 and DAXX, in PBMCs from T1D patients and control subjects. RESULTS: miR-21 expression was increased in controls regarding T1D patients. BCL2 was increased in controls compared to T1D patients in all experimental conditions. DAXX showed different expression patterns between T1D patients and controls (p=0.006). CONCLUSION: Vitamin D showed a possible regulation effect on apoptosis markers mainly through the regulation of BCL2 and DAXX

Hallazgos ecocardiográficos en pacientes con diabetes tipo 1 descompensados en hiperglucemia: Hospital Central Universitario Dr. Antonio María Pineda / Echocardiographic findings in type 1 diabetic patients in hyperglycemia: Hospital Central Universitario Dr. Antonio Maria Pineda

Con el objetivo de describir las características ecocardiográficas de pacientes con diabetes tipo 1 (DT1) descompensados en hiperglucemia de la Unidad de Cuidados Intermedios del Hospital Central Universitario Dr. Antonio María Pineda durante el mes de diciembre 2018-enero 2019, se desarrolló una investigación tipo descriptiva transversal con un total de 25 pacientes los cuales se caracterizaron por un promedio de edad de 20,28 años ± 3,49 años, 56% eran del sexo masculino, 92% asintomáticos cardiovasculares y con un promedio de años de diagnóstico de DT1 de 4,96 ± 3,29 años. Los resultados indican que 20% de los pacientes presentaron disfunción diastólica leve y 44% trastornos de motilidad regional. El promedio de glicemia basal en estos pacientes fue de 209 mg/dL. Los hallazgos funcionales ecocardiográficos no guardaron relación con los años de diagnóstico de la DT1. En conclusión, en estos pacientes se pueden encontrar hallazgos subclínicos de enfermedad cardiovascular en asociación a hiperglucemia persistente por lo que es importante implementar medidas de prevención que retarden las complicaciones micro y macrovasculares de esta enfermedad(AU)

With the aim of describing echocardiographic findings in type 1 diabetic patients with hyperglycemia admitted to the Intermediate Care Unit of the Hospital Central Universitario Dr. Antonio Maria Pineda during the December 2018-January 2019 period, a cross-sectional descriptive study was done in 25 patients with an average age of 20.28 ± 3.49 years, 56% were males, 92% were asymptomatic and had a mean time of diagnosis of 4.96 ± 3.29 years. The results show that 20% of patients had mild diastolic dysfunction and 44% regional motility alterations. Mean glycemic values of these patients was 209 mg/dL. Echocardiographic functional findings were not associated with time of diagnosis of diabetes. Subclinical findings of cardiovascular disease associated with persistent hyperglycemia was found in this group of patients. It is important to implement measures that prevent micro and macrovascular complications of this disease(AU)

Representaciones de pacientes, familiares y equipo de salud en torno a la diabetes infantojuvenil y posibles caminos para su abordaje: análisis de los Talleres de Nutrición realizados en el 2016 en un hospital de San Miguel de Tucuman, Argentina / Representations of patients, family and health team around infant-juvenile diabetes and possible ways to approach: Analysis of the nutrition workshops carried out in 2016 in a Hospital in San Miguel de Tucuman, Argentina

RESUMEN Objetivo: se busca poner de manifiesto las tensiones que surgen en una institución pública de salud de San Miguel de Tucumán, Argentina en relación con la atención y el tratamiento de la diabetes tipo 1. Método: las reflexiones del presente trabajo muestran las conclusiones alcanzadas a partir de un enfoque cualitativo, de abordaje etnográfico en el Ciclo de Talleres de Nutrición llevados a cabo en el Hospital del Niño Jesús de San Miguel Tucumán, Argentina durante el 2016. Los talleres mencionados estaban destinados a pacientes diabéticos -niñas, niños y adolescentes- y a sus padres y madres. La información fue obtenida a través de la observación participante, de entrevistas en profundidad realizadas a pacientes, padres, madres y personal del equipo de salud y del análisis de las producciones escritas realizadas en los talleres. Resultados: se observa que existen representaciones e intereses diferentes entre los grupos de personas involucrados, lo que se traduce en dificultades en la comunicación. Se advierte una concepción adultocéntrica de la infancia que no atiende al presente de las y los pacientes y que les trata más como "objetos" de atención que como "sujetos"; esto ocurre en el marco de una cultura institucional que no apoya a su personal en el desarrollo de experiencias de atención alternativas como el dispositivo de talleres. Conclusiones: se plantea la necesidad de resignificar los modos de entender la salud, la enfermedad y la infancia en el contexto de una enfermedad crónica para ayudar en la adherencia al tratamiento.

ABSTRACT Objective: It seeks to highlight the tensions that arise in a public health institution of San Miguel de Tucumán, Argentina in relation to the care and treatment of type 1 diabetes. Method: The reflections of this work present the conclusions to which it is up from a qualitative approach, of ethnographic approximation in the cycle of workshops of nutrition carried out in the Hospital of the child Jesus of San Miguel Tucumán, Argentina during 2016. The reflections of this work represent the conclusions to which it is up from the analysis of the ethnographic material obtained from the participant observation of the cycle of nutrition workshops carried out in the Hospital of the child Jesus of San Miguel Tucumán, Argentina during the 2016. They were aimed for diabetic patients-girls, boys and adolescents-and their parents. The information was obtained through the participant observation, in-depth interviews with patients, parents and members of the health team and the analysis of the written productions made in the workshops. Results: It is observed that there are different representations and interests among the actors involved which translate into difficulties in the communication; there is a adultcentric conception of childhood that does not attend to the present of patients and treats them more as "objects" of care than as "subjects", this hapens within the framework of an institutional culture that does not support its staff in the development of alternative care experiences such as the workshop device. Conclusions: the need to resignify the ways of understanding health, disease and childhood in the context of a chronic disease to help in adherence to treatment is noted.

Um olhar psicanalítico sobre crianças e adolescentes com diabetes Mellitus tipo 1 e seus familiares / A psychoanalytic approch at children and adolescents with diabetes Mellitus type 1 and its family / Una mirada psicanalítica sobre niños y adolescentes con diabetes Mellitus tipo 1 y sus familiares

Este estudo objetivou compreender os aspectos emocionais de crianças e adolescentes com diabetes tipo 1 (DM1) e seus familiares sob um olhar psicanalítico. Trata-se de um estudo qualitativo realizado por meio de entrevistas semiestruturadas com núcleos familiares de crianças e adolescentes com DM1. Os dados foram analisados de acordo com a análise de conteúdo, elegendo-se três categorias: diagnóstico, atendimento e tratamento. As crianças e adolescentes demonstraram sofrimento psíquico relacionado ao diagnóstico e internação hospitalar, com vivências de luto, sentimentos de desintegração e desproteção. Também denotaram sofrimento associado à restrição alimentar e aplicação da insulina. Continuidade do cuidado e disponibilidade dos membros da equipe interprofissional de saúde refletiram positivamente sobre o sentimento de segurança tanto dos familiares quanto das crianças e dos adolescentes. Na perspectiva da psicanálise, os aspectos emocionais observados nos núcleos familiares de crianças e adolescentes com DM1 afetaram sua condição de saúde, interferindo na aceitação, adesão e controle da doença.

This study aimed to comprehend emotional aspects of children and adolescents with type 1 diabetes (DM1) and their relatives in a psychoanalytic approach. This is a qualitative study carried out through semi-structured interviews with families of children and adolescents with DM1. Data were analyzed according to content analysis on which three categorie were identified: diagnosis, care and treatment. Children and adolescents demonstrated psychic suffering during diagnosis and hospitalization, with experiences of mourning, feelings of disintegration and lack of protection. They also denoted suffering associated with dietary restriction and insulin application. Continuity of care and availability of health interprofessional teamwork reflected positively on the feelings of safety of families, childrens and adolescents. In a psychoanalysis perspective, emotional aspects observed in families of children and adolescents with DM1 affected their health condition, interfering in acceptance, adhesion and control of the disease.

Este estudio objetivó comprender los aspectos emocionales de niños y adolescentes con diabetes tipo 1 (DM1) y sus familiares bajo una mirada psicoanalítica. Se trata de un estudio cualitativo realizado por medio de entrevistas semiestructuradas con núcleos familiares de niños y adolescentes con DM1. Los datos fueron analizados de acuerdo con el análisis de contenido, eligiendo-se tres categorías: diagnóstico, atención y tratamiento. Los niños y adolescentes demostraron sufrimiento psíquico relacionados al diagnóstico e internación hospitalaria, con vivencias de luto, sentimientos de desintegración y desprotección. También denotaron sufrimiento asociado a la restricción alimentaria y aplicación de la insulina. Continuidad del cuidado y disponibilidad de los miembros del equipo interprofesional de salud reflejaron positivamente sobre el sentimiento de seguridad tanto de los familiares como de los niños y adolescentes. Desde la perspectiva psicoanalítica, los aspectos emocionales observados en los núcleos familiares de niños y adolescentes con DM1 afectaron su condición de salud, interfiriendo en la aceptación, adhesión y en el control de la enfermedad.

Utilidad de la prueba de tolerancia de comida mixta con Nutrial I para la evaluación de la función de las células beta en diabetes tipo 1 / Usefulness of the tolerance test of mixed food with Nutrial I for the assessment of beta cells function in diabetes type 1

RESUMEN Introducción: La prueba de tolerancia de comida mixta es considerada la prueba de oro para la medición de la producción de insulina endógena en pacientes con diabetes tipo 1. Objetivo: Determinar la utilidad de la prueba de tolerancia de comida mixta con Nutrial I para evaluar la función de las células ß en diabéticos tipo 1 de diagnóstico reciente y la relación de esa función con algunas características clínicas y bioquímicas. Métodos: Se estudiaron variables bioquímicas como la glucemia, hemoglobina glucosilada (HbA1c), péptido C y fracciones lipídicas. La prueba de tolerancia de comida mixta con Nutrial I se aplicó a 18 sujetos con diabetes tipo 1 de diagnóstico reciente y a 8 voluntarios con edades comprendidas entre 19 y 35 años. El consumo del suplemento Nutrial I se calculó según el peso del paciente. Se obtuvieron muestras para glucemia y péptido C a los -10, 0, 30, 60, 90 y 120 minutos. Resultados: Se observaron concentraciones elevadas de glucemia y disminuidas de péptido C durante la prueba de tolerancia de comida mixta en los diabéticos tipo 1 de diagnóstico reciente, en comparación con los voluntarios, así como, diferencias en las áreas bajo la curva de péptido C (AUC-pc) (p= 0,001). En los diabéticos tipo 1 de diagnóstico reciente se evidenció una correlación negativa entre el AUC-pc con los niveles de glucemia en ayunas (r= -0,747; p ( 0,0001) y la HbA1c (r= -0,535; p= 0,022). Por el contrario, se encontró una correlación positiva entre el AUC-pc y el péptido C en ayunas (r= 0,722; p= 0,001). El AUC-pc después de la prueba de tolerancia de comida mixta es mayor en los sujetos con glucemia en ayunas si GA < 7 mmol/L con respecto a los sujetos con glucemia en ayunas ( 7 mmol/L (p= 0,012). Conclusiones: El empleo del Nutrial I en la prueba de tolerancia de comida mixta fue útil en la evaluación de la función de las células β en diabéticos tipo 1 de diagnóstico reciente. Los valores bajos de glucemia en ayunas durante esta prueba son marcadores indirectos de una función residual de células ( más conservada en los diabéticos tipo 1 de diagnóstico reciente(AU)

ABSTRACT Introduction: The tolerance test of mixed food is considered the gold standard for the measurement of endogenous insulin production in patients with diabetes type 1. Objective: To determine the usefulness of the tolerance test of mixed food with Nutrial I to assess the ß-cells function in patients with diabetes type 1 of recent diagnosis and the relation of this function with some clinical and biochemical characteristics. Methods: There were studied biochemical variables as the blood glucose, glycosylated haemoglobin (HbA1c), C-peptide and lipid fractions. The tolerance test of mixed food with Nutrial I was applied to 18 individuals with diabetes type 1 of recent diagnosis and in 8 volunteers aged between 19 and 35 years old. The consumption of Nutrial I supplement was calculated according to the weight of the patient. Samples were obtained for blood glucose and C-peptide at -10, 0, 30, 60, 90 and 120 minutes. Results: There were observed high concentrations of glycemia and decreased amounts of C-peptide during the tolerance test of mixed food in recently diagnosed type 1 diabetics in comparison with the volunteers, as well as differences in areas under the curve of C-peptide (AUC-pc) (p= 0.001). In the recently diagnosed type 1 diabetics was evident a negative correlation between the AUC-pc with fasting plasma glucose levels (r= -0,747; p(0.0001) and HbA1c (r= -0,535; p= 0.022). On the contrary, it was found a positive correlation between the AUC-pc and fasting C-peptide (r = 0.722; p = 0.001). The AUC-pc after the tolerance test of mixed food was greater in subjects with fasting blood glucose < 7 mmol/L with respect to the subjects with fasting blood glucose ( 7 mmol/L (p= 0.012). Conclusions: The use of Nutrial I in the tolerance test of mixed food was useful in the assessment of the role of the β-cells in patients with recently diagnosed diabetes type 1. Low values of fasting blood glucose during this test are indirect markers of a residual function of (cells more preserved in type 1 diabetics of recent diagnosis(AU)

Apego y estrés en niños con Diabetes tipo 1 y sus madres / Attachment and stress in children with type 1 Diabetes and their mothers

Resumen: Objetivo: Comprender la relación entre apego y diabetes y el rol mediador del estrés en niños con diabetes mellitus tipo 1 (DM1) y sus madres. Material y Método: Se aplicaron Instrumentos de evaluación correspondientes a Escalas de Apego (ECR-R), Estrés percibido (PSS), Seguridad (SS) y Estrés en niños (SiC), como medidas de autoreporte completadas por niños(as) y sus madres. Se analizaron variables demográficas, tiempo de inicio de diabetes, y el promedio de las ultimas 3 medi ciones de Hemoglobina glicosilada HbA1c como parámetro del control metabólico del último año. Resultados: Las estrategias de apego maternas e infantiles y el estrés materno mostraron una asocia ción significativa con los resultados de la diabetes del niño(a), aunque con importantes diferencias de género. Conclusiones: Las estrategias de apego, infantiles y maternas, son relevantes en el curso de la diabetes.

Abstract: Objective: To understand the relationship between attachment and diabetes and the role of stress mediators in children with type 1 diabetes (T1D) and their mothers. Material and Method: The following assessment instruments were applied as self-report measures: Attachment Scale (ECR- R), Perceived Stress Scale (PSS), Security Scale (SS), and the Stress in Children (SiC) questionnaire, which were completed by children and their mothers. We analyzed demographic variables, diabetes onset time, and the average of the last three glycosylated hemoglobin (HbA1c) measurements as a parameter of metabolic control in the last year. Results: Attachment strategies of both mother and child, as well as maternal stress, showed a significant association with the child's diabetes outcomes, although with important gender differences. Conclusions: Both mother and child attachment strate gies are relevant aspects of the T1D course.

Cetoacidosis diabética durante el embarazo: reporte de un caso / Diabetic ketoacidosis in pregnancy: a case report

Resumen ANTECEDENTES: La cetoacidosis diabética es una complicación grave de la diabetes que, a menudo, resulta en una emergencia médica. Puede afectar a mujeres con diabetes tipo 1 y 2 y raramente a mujeres con diabetes gestacional (1-3% de todas las pacientes que cursan con diabetes durante el embarazo). OBJETIVO: Reportar el caso de una paciente embarazada, con cetoacidosis diabética. Por la baja frecuencia de este padecimiento resulta interesante su informe y revisar la bibliografía. CASO CLÍNICO: Paciente de 32 años, con 40.1 semanas de embarazo, con diabetes mellitus tipo 2 descompensada. Acudió a un centro de primer nivel de atención debido a: tensión arterial 145-95 mmHg, dolor en el epigastrio, actividad uterina irregular, náusea y vómito. Fue referida al Hospital General de Chimalhuacán. La paciente ingresó al servicio de Urgencias con: presión arterial 145-96 mmHg, frecuencia cardiaca 87 lpm, temperatura 37.2 oC, frecuencia cardiaca fetal 180 lpm, sostenida. Los estudios de laboratorio reportaron: glucemia de 553 mg/dL, cetonemia, pH 7.3. Debido a la taquicardia fetal sostenida se decidió finalizar el embarazo mediante cesárea. De acuerdo con los criterios diagnósticos de cetoacidosis diabética se estableció el diagnóstico de cetoacidosis diabética moderada. CONCLUSIONES: La cetoacidosis diabética es una complicación rara y grave, con consecuencias nocivas para el feto y la madre. El reconocimiento rápido de los factores precipitantes, la administración inicial de líquidos, insulina y la corrección del desequilibrio hidroelectrolítico son prioridades para revertir la cetoacidosis diabética.

Abstract BACKGROUND: Diabetic ketoacidosis is a serious complication of diabetes that often results in a medical emergency. It usually occurs in patients with type 1 diabetes mellitus, especially newly developed, but it can also affect women with type 2 diabetes and rarely women with gestational diabetes (1-3% of all patients with diabetes during the pregnancy). OBJECTIVE: To present a case report of a pregnant woman who presented with diabetic ketoacidosis, treatment and evolution. Given the low frequency of the pathology, it is interesting to report and review the current literature. CLINICAL CASE: A 32-year-old woman, with the diagnosis of decompensated type 2 diabetes mellitus, 40.1 weeks of gestation, who goes to a first level hospital for presenting; arterial tensions of 145 / 95mmHg, pain in epigastrium, irregular uterine activity, nausea and vomiting for what is referred to the General Hospital of Chimalhuacán. The patient enters the emergency department with, blood pressure 145/96 mmHg, heart rate 87x`, temperature 37.2 °C Fetal heart rate 180 beats per minute sustained, laboratory studies found glycaemia of 553 mg/dL, ketonemia, pH 7.3, fetal heart rate 180 beats per minute sustained so it is decided to terminate the pregnancy by caesarean section. According to the diagnostic criteria of diabetic ketoacidosis, the diagnosis of moderate diabetic ketoacidosis is established. CONCLUSIONS: Diabetic ketoacidosis is a rare but serious complication of diabetes in pregnancy, with harmful consequences for both the fetus and the mother. Rapid recognition of precipitating factors, initial fluid therapy, insulin administration and correction of hydroelectrolytic imbalance are priorities in the management of diabetic ketoacidosis. A multidisciplinary management that includes intensive care unit for the mother and neonatal intensive care, monitoring the maternal response to treatment is essential to reduce morbidity and mortality; fetal monitoring is necessary, as this will be directly affected or benefited according to the maternal response to treatment.

Relationship between bullying and type 1 diabetes mellitus in children and adolescents: a systematic review / Relação entre o bullying e diabetes mellitus tipo 1 em crianças e adolescentes: uma revisão sistemática

Abstract Objective: To carry out a systematic review on the relationship of bullying with type 1 diabetes in children and adolescents. Methods: Systematic review, according to the PRISMA methodology, in which the databases PubMed, Web of Science, Scopus, Thomson Reuters, Eighteenth Century Collections Online, Begell House Digital Library, LILACS, and SciELO were searched using the terms "bullied", "aggression", "peer victimization", "victimization", "school violence", "diabetes mellitus", "type 1 diabetes mellitus", "autoimmune diabetes", "children" and "adolescents." The authors included original studies, involving bullying associated with type 1 diabetes, with children and adolescents, without language restriction and publication period, with texts available in full. Results: Of the 32 articles found, four studies met the selection criteria. Of these studies 85.7% identified occurrence of victimization in diabetics or found a higher frequency in diabetic children and adolescents when compared with young people with other chronic conditions or with healthy peers. Association between bullying and worse glycemic control was observed in two studies, and all the studies mention the fact that type 1 diabetes is a limiting factor for socialization related to diabetes, with less social support and difficulties for the management of the disease in public environments, such as school. The type of bullying suffered varied, including physical, verbal, social, psychological, and sexual. Conclusion: Most of the studies showed an association between bullying and type 1 diabetes when compared to individuals with no such condition. Knowledge of this association has become essential for the follow-up of these patients and the implementation of preventive programs.

Resumo: Objetivo: Realizar uma revisão sistemática sobre a relação do bullying com o diabetes tipo 1 em crianças e adolescentes. Métodos: Revisão sistemática, conforme a metodologia PRISMA, onde foram pesquisadas as bases de dados Pubmed, Web of Science, Scopus, Thomson Reuters, Eighteenth Century Collections Online, Begell House Digital Library, Lilacs e SciELO, usando os termos"bullying", "bullied", "aggression", "peer victimization", "victimization", "school violence", "diabetes mellitus", "type 1 diabetes", "type 1 diabetes mellitus", "autoimmune diabetes", "children" and "adolescents". Foram incluídos estudos originais, envolvendo bullying associado ao diabetes tipo 1, com população de crianças e adolescentes, sem restrição de idioma e período de publicação, com textos disponíveis na íntegra. Resultados: Dos 32 artigos encontrados, quatro atenderam aos critérios de seleção. Desses estudos, 85,7% identificaram ocorrência de vitimização em diabéticos ou constataram maior frequência em crianças e adolescentes diabéticos quando comparados com jovens com outras condições crônicas ou sadios. Associação entre bullying e pior controle glicêmico foi observada em dois estudos e todos os estudos mencionam o fato de ser portador do diabetes tipo 1, um fator limitante para socialização relacionado ao diabetes, com menor apoio social e dificuldades para o manejo da doença em ambientes públicos, como a escola. O tipo de bullying sofrido variou entre físico, verbal, social, psicológico e sexual. Conclusão: A maioria dos estudos evidenciou associação entre vitimização por bullying e diabetes tipo 1, quando comparada com indivíduos com ausência dessa condição. O conhecimento dessa associação torna-se fundamental para acompanhamento desses pacientes e implantação de programas preventivos.

Terapia complementaria a la insulina en el tratamiento de niños y adolescentes con diabetes mellitus tipo 1- (DM1) / Therapies complementaries to insulin in the treatment of children and adolescents with type 1 diabetes mellitus (T1DM)

La diabetes mellitus tipo 1 (DM1), es una enfermedad crónica caracterizada por la deficiencia de insulina debido a la pérdida de células ß pancreáticas, las alteraciones hormonales en la DM 1 no se limitan a la deficiencia de insulina; existiendo también secreción inadecuadada de glucagón en el período postprandial. Aunque el control glucémico con terapias intensivas con insulina ha reducido la incidencia de complicaciones microvascular y macrovasculares. La mayoría de las personas con DM1 tienen un control glucémico subóptimo; Por lo tanto, el uso de farmacoterapia adyuvante para mejorar el control ha sido de interés clínico. El uso de estos nuevos medicamentos brindaría la oportunidad de imitar más de cerca la fisiología pancreática normal, y contrarrestar otros mecanismos fisiopatológicos diferentes a Insulinopenia; contribuyendo a lograr un mejor control metabólico y expectativa de vida.

Type 1 diabetes mellitus (T1DM), is a chronic disease characterized by insulin deficiency due to the loss of pancreatic ß cells, the hormonal alterations in T1DM are not limited to insulin deficiency; there is also a deregulated glucagon secretion in the postprandial period. Although glycemic control with intensive therapies with insulin has reduced the incidence of microvascular and macrovascular complications, most people with T1DM1 glycemic control; therefore, the use of adjuvant pharmacotherapy to improve control has been of clinical interest. The use of these new drugs would offer the opportunity to imitate more closely the normal pancreatic physiology, and to counteract other physiopathological mechanisms different from insulinopenia; contributing to achieve better metabolic control and life expectancy.

The antioxidant status of coenzyme Q10 and vitamin E in children with type 1 diabetes / Estado antioxidante da coenzima Q10 e da vitamina E em crianças com diabetes tipo 1

Abstract Objective: The purpose of this study was to evaluate the antioxidant status of plasma vitamin E and plasma and intracellular coenzyme Q10 in children with type 1 diabetes. Method: This case-control study was conducted on 72 children with type 1 diabetes and compared to 48 healthy children, who were age, sex, and ethnicity-matched. The diabetic children were divided according to their glycosylated hemoglobin (A1c %) into two groups: poor and good glycemic control groups. All children underwent full history taking, clinical examination, and laboratory measurement of complete blood count, A1c %, plasma cholesterol, triglycerides, and vitamin E levels and coenzyme Q10 levels in plasma, erythrocytes, and platelets. Results: Children with poor glycemic control showed significantly higher plasma vitamin E, coenzyme Q10, triglycerides, low-density lipoproteins, waist circumference/height ratio, cholesterol levels, and lower high-density lipoproteins and platelet coenzyme Q10 redox status in comparison to those with good glycemic control and the control group (p < 0.05). Plasma coenzyme Q10 showed a positive correlation with the duration of type 1 diabetes, triglycerides, cholesterol, vitamin E, and A1c %, and negative correlation with the age of the diabetic group (p < 0.05). The platelet redox status showed a negative correlation with the A1c % levels (r = −0.31; p = 0.022) and the duration of type 1 diabetes (r = −0.35, p = 0.012). Conclusion: Patients with type 1 diabetes, especially poorly controlled, had elevation of plasma vitamin E and coenzyme Q10 levels and decreased platelet redox status of coenzyme Q10, which may be an indicator of increased oxidative stress.

Resumo Objetivo: Avaliar o estado antioxidante da vitamina E no plasma e da coenzima Q10 no plasma e intracelular em crianças com diabetes tipo 1. Método: Este estudo caso-controle realizado em com 72 crianças com diabetes tipo 1 comparadas por idade, sexo e etnia de 58 crianças saudáveis. As crianças diabéticas foram divididas em dois grupos de acordo com sua hemoglobina glicosilada (A1c %): grupos de controle glicêmico bom e baixo. Todas as crianças foram submetidas a anamnese total, exame clínico e laboratorial para hemograma completo, A1c %, colesterol no plasma, triglicerídeos e níveis de vitamina E e níveis de coenzima Q10 no plasma, eritrócitos e plaquetas. Resultados: As crianças com baixo controle glicêmico mostraram nível de vitamina E no plasma significativamente maior, coenzima Q10, triglicerídeos, lipoproteína de baixa densidade, proporção da circunferência da cintura/estatura e níveis de colesterol e menor nível de lipoproteína de alta densidade e estado redox da coenzima Q10 em comparação aos com bom controle glicêmico e com o grupo de controle (p < 0,05). A coenzima Q10 no plasma mostrou correlação positiva com a duração da diabetes tipo 1, triglicerídeos, colesterol, vitamina E e A1c % e correlação negativa com a idade do grupo diabético (p < 0,05). O estado redox das plaquetas mostrou correlação negativa com os níveis de A1c % (r = -0,31; p = 0,022) e a duração da diabetes tipo 1 (r = -0,35, p = 0,012). Conclusão: Os pacientes com diabetes tipo 1, principalmente mal controlados, apresentaram aumento nos níveis de vitamina E no plasma e coenzima Q10 e redução no estado redox das plaquetas da coenzima Q10 que podem indicar aumento do estresse oxidativo.

Mesa 2: Diabetes Mellitus Tipo 1 y actividad física / Table 2: Diabetes Mellitus Type 1 and physical activity

En personas con diabetes tipo 1 (DM1) el ejercicio físico realizado en forma regular brindaría protección cardiovascular y tendría propiedades inmunomoduladoras pero la compleja interacción entre los efectos del ejercicio sobre el metabolismo glucídico y la terapia con insulina exógena supone un verdadero desafío. El ejercicio aeróbico por la contracción muscular disminuye la glucemia, conduce a un estado de hiperinsulinemia relativa y genera hipoglucemia al inicio o después del mismo mientras que el ejercicio anaeróbico se asocia a hiperglucemia por aumento de catecolaminas e incremento de lactato que favorece la neoglucogénesis hepática. El deterioro de la respuesta de hormonas contrarreguladoras existente en la DM1 amplifica la variabilidad glucémica y dificulta el control metabólico. Existen guías y recomendaciones que buscan brindar un marco de seguridad para la prescripción de actividad física considerando la multiplicidad de disciplinas deportivas, la edad del paciente y la evaluación de las complicaciones crónicas de la diabetes antes del inicio de la misma. Entre las estrategias terapéuticas se encuentran la modulación con hidratos de carbono, la adecuación pre y pos ejercicio de la insulinoterapia y el control intensivo de glucemia y cetonas. Los nuevos infusores de insulina y monitoreo glucémico ofrecen la posibilidad del fraccionamiento y/o suspensión de dosis convirtiéndose en el gold standard entre los deportistas de alto rendimiento. A futuro modelos integrados con calculadoras de ejercicio inteligentes, capacidad predictiva y de "aprendizaje individualizado" (páncreas artificial) posibilitarán mantener la euglucemia y optimizar los beneficios del ejercicio como parte del tratamiento

Avaliação do papel de HSPB1 na modulação da autofagia induzida por PRL em células-beta / Unveiling the role of HSPB1 in PRL-induced autophagy modulation in beta-cells

O diabetes mellitus tipo 1 é uma doença metabólica, caracterizada pela desregulação glicêmica, que ocorre devido a um ataque autoimune. A insulinoterapia é o tratamento clássico para o DM1. Contudo, alguns pacientes que apresentam essa doença não respondem de forma eficiente a este tratamento e apresentam episódios frequentes de hipoglicemia severa e despercebida (pacientes hiperlábeis). Essas complicações comprometem de forma significativa a qualidade de vida dessas pessoas. O transplante de ilhotas é uma importante alternativa para o tratamento de pacientes hiperlábeis com DM1. No entanto, essa terapia apresenta restrições como a necessidade de mais de um doador por transplante e significativa morte das ilhotas devido ao estresse provocado pelo procedimento de isolamento, além da morte promovida pelo sistema imune do paciente nos primeiros momentos pós-transplante. A autofagia é um mecanismo de reciclagem de componentes citoplasmáticos que é fundamental para a homeostase celular. Em condições de estresse, este mecanismo é ativado acima do seu nível basal, promovendo a degradação de agregados proteicos e organelas defeituosas, evitando assim, danos celulares que comprometam a viabilidade da célula. Trabalhos realizados por nosso grupo têm mostrado a citoproteção que PRL promove em células-beta, reduzindo a apoptose induzida por citocinas pró-inflamatórias. Também demonstramos o papel essencial de HSPB1 na inibição de apoptose induzida por PRL após o tratamento com citocinas. Além disso, resultados recentes de nosso laboratório mostraram um aumento nos níveis de autofagia em células-beta após sua exposição a citocinas, bem como uma restauração a níveis normais na presença de PRL. Visando um melhor entendimento do papel da PRL na modulação da autofagia em células-beta, o objetivo desse projeto foi estudar se HSPB1 também é essencial no mecanismo de regulação da autofagia induzido por PRL.Para tal, fizemos experimentos em modelos de células-beta MIN6, MIN6 silenciadas para HSPB1 (MIN6-shHSPB1) e MIN6 com sequencia short hairpin aleatória (MIN6- SsC), medindo a morte celular através de ensaios de viabilidade, e ensaios de western blot para avaliar os níveis de marcadores de autofagia e fluxo autofágico (degradação de autofagossomos), tratando as células com citocinas, prolactina e indutores ou inibidores de autofagia. Os resultados mostraram que a modulação da autofagia ocasionada pela prolactina em células-beta se dá, em parte, através de HSPB1. O tratamento com prolactina foi capaz de inibir a morte celular induzida por citocinas, mesmo na presença de cloroquina, um bloqueador de autofagia, o que nos levou a concluir que a autofagia não é uma via envolvida na citoproteção de células beta induzida por PRL. Os resultados gerados nesse estudo contribuíram para uma melhor compreensão dos eventos moleculares induzidos por PRL em células-beta, e poderão permitir a inferência de novas abordagens que melhorem a citoproteção, cultura e transplante dessas células em pacientes com diabetes tipo 1

Type 1 diabetes mellitus is a metabolic disease characterized by glycemic dysregulation, which occurs due to an autoimmune destruction of beta-cells. Insulin therapy is the gold standard treatment for DM1. However, some DM1 patients do not respond efficiently to this treatment and suffer frequent episodes of severe hypoglycemia unawareness. Since this complication jeopardizes the quality of life of these people, Islet transplantation is a therapeutic alternative indicated to treat these patients. However, besides the lack of enough organ donors, the loss of beta cells during both the isolation as well as the infusion of islets into the recipient induce a great estresse and thus a significant cell death is one of the drawbacks of this procedure. Autophagy is a mechanism of recycling cytoplasmic components and is essential for cellular homeostasis. Under estresse conditions, this mechanism is activated above basal levels, promoting the degradation of protein aggregates and defective organelles, thus avoiding cell damage that could compromise cell viability. Studies carried out by our group have shown not only that PRL promotes cytoprotection in beta-cells, reducing pro-inflammatory cytokines-induced apoptosis, but also that HSPB1 plays an essential role in this inhibition of apoptosis mediated by PRL after treatment with cytokines. Moreover, recent results from our laboratory showed an increase in autophagy levels in beta-cells after exposure to cytokines, as well as a restauration to normal levels in the presence of PRL. In order to better understand the role of PRL in the modulation of autophagy in these cells, the aim of this project is to study whether HSPB1 is also essential in the mechanism of autophagy regulation induced by PRL. Using MIN6 beta cell models where HSPB1 was silenced (MIN6-shHSPB1) or not (MIN6-SsC), we studied cell death by viability assays. Moreover, western blot assays were performed in order to assess levels of autophagy and autophagic flux markers in the cells.Our results showed that HSPB1 in one of the mediators of PRL-induced modulation of autophagy. Nevertheless, since hormonal treatment was still able to inhibit cytokinesinduced cell death even in the presence of chloroquin, an autophagy blocker, we conclude that autophagy is not a signaling pathway involved in PRl-induced beta-cell cytoprotection. Altogether, the results shown in this study may help to increase the knowledge of the molecular events induced by PRL in beta-cells, and may allow to infer new approaches to improve cytoprotection, culture and transplantation of these cells into type 1 diabetic patients

Hipoglucemia en pacientes con diabetes tipo 1 y tipo 2 en tratamiento con insulina. Resultados del estudio HAT en argentina / Hypoglycaemia in patients with type 1 and type 2 diabetes mellitus on insulin therapy. Results of the global HAT study in Argentina

Describimos los resultados del estudio internacional no intervencionista HAT en una muestra de Argentina que evaluó las hipoglucemias graves y no graves en 433 pacientes con diabetes mellitus tipo 1 (DMT1) y 823 con diabetes tipo 2 (DMT2) tratados con insulina, mediante un cuestionario de autoevaluación doble (retrospectivo y prospectivo). La incidencia anual de al menos un evento de hipoglucemia fue 46 episodios/paciente-año en DMT1 y 14.2 en DMT2 (retrospectivo) y 96.5 y 24.6 eventos/paciente/año en DMT1 y DMT2, respectivamente (prospectivo). La hipoglucemia influyó en la calidad de vida (en escala 0-10 de temor a hipoglucemia: 60% en DMT1 y 37.6% en DMT2 puntuó de 5 a 10), en el desempeño cotidiano, laboral o académico (2.1% con DMT1 y el 3.2% con DMT2 no asistieron a su labor por hipoglucemia) y en el mayor consumo de recursos (en DMT1: 66.1% aumentó el monitoreo glucémico, 60.5% la ingesta, 51% las consultas y 60.5% redujo la insulina y el 20.9% el ejercicio, con 3.5% de internación, y en DMT2 aumentó un 46.2% el monitoreo glucémico, 43.8% las consultas, 38.6% la ingesta, el 24.1% redujo y el 13.9% salteó la dosis de insulina, 14.3% suspendió el ejercicio). Se registró mayor número de episodios en el período prospectivo. Es necesario contar con un instrumento para evaluar las hipoglucemias en la práctica clínica y con estrategias para reducir su riesgo. También es importante indagar sobre los episodios y reforzar la educación de pacientes y familiares sobre ajustes de tratamiento ante episodios de hipoglucemia.

We describe the results of the HAT study in 433 Argentinean patients with type 1 diabetes (T1D) and 823 with type 2 diabetes (T2D). HAT was an international non-interventional study assessing severe and non-severe hypoglycaemia in patients with T1D and T2D under insulin treatment through a two-part self-assessment questionnaire (retrospective and prospective). The annual incidence of at least one hypoglycaemic episode was 46 episode/patient/year in T1D and 14.2 in T2D (retrospective), 96.5 and 24.6 episode/patient/year in T1D and T2D, respectively (prospective). Hypoglycaemia affected quality of life (on a scale of 0-10 for fear of hypoglycaemia: 60% in T1D and 37.6% in T2D scored 5 to 10), daily life, occupational or academic performance (2.1% with T1D and 3.2% with T2D did not attend to their work after hypoglycaemia), and induced an increased use of health resources (T1D: 66.1% increased glucose monitoring, 60.5% food intake, 51% consultations, 3.5% hospital admissions; 60.5% reduced insulin and 20.9% exercises; T2D increased 46.2% glucose monitoring, 43.8% consultations, 38.6% food intake, 24.1% reduced and 13.9% skipped the insulin dose and 14.3% suspended exercises). Greater numbers of episodes were recorded in the prospective period. An instrument to assess hypoglycaemia in clinical practice and strategies to reduce their risk are required. It is also important to ask about the episodes and reinforce the education of patients and close relatives on hypoglycaemia prevention and treatment.

Melhores práticas de enfermagem em educação em diabetes à criança hospitalizada: uma revisão integrativa / Best nursing practices in diabetes education for the hospitalized child: an integrative review

A incidência do Diabetes Mellitus tipo 1 (DM1) tem aumentado nos últimos anos, com consequente incremento de hospitalizações de crianças por primodescompensação diabética, com crescente necessidade de processo educativo. Diante desta realidade, objetivou-se identificar na literatura as melhores práticas de enfermagem em educação em diabetes para crianças com DM1 hospitalizadas e sua família. Foi realizada uma revisão integrativa, com os descritores: Diabetic Ketoacidosis, Diabetes Education, Nursing e Child, Hospitalized, e busca livre em revistas de referência e artigos similares. Foram selecionados quatro estudos, e identificadas três categorias: Envolvimento e Empoderamento da Família no Processo Educativo em Diabetes; Atuação da Equipe Multiprofissional; Definição e Conteúdo do Processo Educativo, concluindo que o processo educativo deve incluir a família, ser realizado por uma equipe multiprofissional e fundamentado em evidências científicas. Poucos estudos foram encontrados, evidenciando necessidade de mais pesquisas na área.

The incidence of Diabetes Mellitus type 1 (DM1) has increased in the last years, with a consequent growth of child hospitalizations due to diabetic prime decompensation, with growing need of an educational process. Thus, our objective was to identify in the literature the best nursing practices in diabetes education for hospitalized children with DM1 and their families. We conducted an integrative review with the descriptors: Diabetic Ketoacidosis, Diabetes Education, Nursing and Child, Hospitalized, and the free search in reference journals and similar articles. We selected four studies, and we identified three categories: Family Involvement and Empowerment in the Diabetes Educational Process; Performance of the Multi-professional Team; Definition and Content of the Educational Process. We concluded that the educational process should include the family, it should be conducted by a multi-professional team and based on scientific evidence. We identified few studies, showing the need for more studies in the field.

Alteraciones bucales asociadas a Diabetes mellitus tipo 1 en niños y adolescentes. Instituto de Endocrinología. Cuba. 2014-2015 / Buccal alterations associated to Type 1 Diabetes Mellitus in children and adolescents. Institute of Endocrinology. Cuba. 2014-2015

Introducción: La Diabetes Mellitus tipo 1 es una enfermedad sistémica crónica con repercusión a nivel bucal. Elevadas concentraciones de glucosa sanguínea de manera sostenida generan disminución del flujo salival, disminución de la respuesta vascular periférica lo que contribuye a la acumulación de placa bacteriana y tártaro, al desarrollo de caries, halitosis y enfermedad periodontal. Objetivo: Determinar la asociación de las alteraciones bucales y la Diabetes Mellitus tipo 1 en niños y adolescentes. Material y Métodos: Se realizó un estudio observacional de casos y controles, con un grupo de niños y adolescentes con Diabetes Mellitus tipo 1 (Grupo 1), de edades comprendidas entre 3 a 18 años y un grupo de niños y adolescentes sin Diabetes Mellitus (Grupo 2) de edades y sexo comparables. Resultados: Los pacientes con diabetes resultaron más afectados por xerostomía (37.8 por ciento), úlceras (55.6 por ciento) y periodontopatías (71.1 por ciento) que los pacientes sin diabetes, siendo estos resultados muy significativos estadísticamente, a diferencia de la afectación por caries dental y el comportamiento de la higiene bucal donde las diferencias no fueron estadísticamente significativas. Conclusiones: La Diabetes Mellitus tipo 1 se relaciona con las alteraciones bucales, así los niños y adolescentes diabéticos presentan mayor frecuencia de periodontopatías, xerostomía y úlceras que los niños y adolescentes sin diabetes, no sucede así con la caries dental ni la higiene bucal(AU)

Introduction: Type 1 Diabetes Mellitus is a chronic systemic disease with a repercussion upon a buccal level. High concentrations of maintained blood glucose generate a decrease of both the salivary flow and the peripheral vascular response, which contributes to the accumulation of bacterial plaque and tartar, the growth of cavities, halitosis, and periodontal diseases. Objective: To determine the association between buccal alterations and Type 1 Diabetes Mellitus in children and adolescents. Material and Methods: A case-control observational study was done in a group of children and adolescents with Type 1 Diabetes Mellitus (Group 1), from ages 3 to 18, and in a group of children and adolescents without Diabetes Mellitus (Group 2), of compared ages and sexes. Results: The patients with diabetes were more affected by xerostomia (37.8 percent), ulcers (55.6 percent), and periodontopathies (71.1 percent) than the patients without diabetes, being these results very significant statistically, unlike the affectation by dental cavities and the behavior of buccal hygiene where the differences were not statistically significant. Conclusions: Type 1 Diabetes Mellitus is related to buccal alterations; this way, diabetic children and adolescents present more frequent periodontopathies, xerostomies and ulcers than children and adolescents without diabetes, but it does not happen with dental cavities or buccal hygiene(AU)

Cetosis normoglicémica en adolescente con diabetes tipo 1 recibiendo insulina y dapaglifozina: Reporte de un caso / Euglycemic ketosis in an adolescent with type 1 diabetes on insulin and dapaglifozin: Case report

Dapaglifozina, un inhibidor del cotransportador de sodio-glucosa 2 (I-SGLT2) induce glucosuria y reduce la glicemia en adultos con diabetes tipo 2. Objetivo: Presentar una cetosis diabética “normoglicémica” en una adolescente con diabetes tipo 1 (DM1) que recibía dapaglifozina y alertar sobre el riesgo del uso I-SGLT2 que parece promisorio, pero no está aprobado en niños ni en DM1. Caso clínico: Paciente de 17 años sin cetosis durante 9 años con DM1, inició dapaglifozina 10 mg/día para reducir la insulina y el peso. Durante 11 meses de tratamiento tuvo cetonas capilares indetectables, redujo el índice de masa corporal 23,9 a 21,1 kg/m², la insulina basal 40 a 17 U, la hemoglobina glicosilada 8,3 a 7,5%, la glicemia capilar 175 a 161 mg/dl y la variabilidad de la glucosa (desvío estándar 85 a 77). Inesperadamente aparecieron náuseas y vómitos. La paciente portaba bomba de insulina con monitorización continua de glucosa, bien calibrada (glucosas intersticiales concordantes con glicemias), que mostraba glucosa estable bajo 200 mg/dl. Recibió insulina pero los vómitos persistieron; en tres horas, aparecieron deshidratación y desmayos, con cetonas 4,6 nmol/l y glicemia 224 mg/dl. Recibió suero fisiológico, ondansetrón, carbohidratos y varias dosis de insulina con pronta recuperación del estado general e hidratación, sin embargo, la cetosis continuó durante 24 horas. Cabe destacar que la bomba estaba funcionando bien y no se cambió la cánula. Al superar la cetosis, continuó con la misma cánula con buen control metabólico. Conclusión: Es importante sospechar la cetosis diabética normoglicémica por ser de riesgo vital.

Dapagliflozin, an insulin-independent sodium-glucose cotransporter 2 inhibitor (SGLT2-I) induces glycosuria and reduces hyperglycemia in adults with type 2 diabetes. Objective: To present an “euglycemic” diabetic ketosis in an adolescent with type 1 diabetes (T1D) receiving dapagliflozin, to alert about the risk of a drug not approved in children nor in T1D. Case report: A 17 years old adolescent with T1D during 9 years, was started on dapagliflozin 10 mg / day to reduce insulin dose and weight. During 11 months on treatment, capillaries ketones were undetectable and she exhibited a reduction in body mass index 23.9 to 21.1 kg/m2, basal insulin 40 to 17 U, glycated hemoglobin 8.3 to 7.5%, capillary glucose 175 to 161 mg/dl and glucose variability (standard deviation) 85 to 77. Suddenly nausea and vomits appeared. The patient was on an insulin pump and well calibrated continuous glucose monitoring, showing stable glucose levels under 200 mg/dl, and an insulin bolus was delivered. Vomiting without hyperglycemia persisted; three hours later, she was severely dehydrated and fainting, with ketones 4.6 nmol/l and glucose 224 mg/dl. She received IV saline fluids, ondansetron, carbohydrates and several insulin boluses. Hydration and general condition improved soon, however despite several insulin doses, ketosis continued for 24 hours. It is remarkable that the pump was working well and the cannula was not changed. After the ketosis was resolved, she continued using the same cannula with good metabolic control. Conclusion: Euglycemic ketosis is a life-threatening condition that must be suspected.

Comportamento glicêmico após exercícios intermitentes em diabéticos tipo 1: Uma revisão sistemática / Glycemic behavior after intermittent exercises on type 1 diabetics: A systematic review

a presente revisão sistemática busca evidências sobre o efeito agudo da realização de exercícios intermitentes na resposta glicêmica de pessoas com diabetes tipo 1. Métodos: realizaram-se buscas nas bases de dados eletrônicas: Pubmed e Medline. Foram utilizados os seguintes descritores em português e Inglês: Intermittent exercises, interval exercises, intermittent high intensity e diabetes type 1. Foram encontrados 2166 artigos com os descritores mencionados, destes após processo de seleção ficaram 13 artigos para a leitura na integra aonde 06 foram excluídos, assim ao final 07 artigos contemplaram todos os critérios de inclusão e exclusão. O levantamento de dados restringiu-se a pesquisas realizadas com seres humanos de ambos os gêneros nos últimos 10 anos (2005 a 2015). Resultados: observou-se que com a prática de 20 a 60 minutos de exercícios com sprints máximos intermitentes ((variação entre 4 a 30 sprints, tempo de duração 4 a 15 segundos), intervalados com períodos de recuperação passivo ou recuperação ativa de intensidade moderada (40% VO²máx e 50% VO²pico), o que se pode esperar é uma queda glicêmica entre 36 + 14.4mg/dl a 90 + 9mg/dl com valores percentuais entre 18,18% a 54,05%. Conclusão: segundo os estudos analisados o exercício intermitente favorece a um menor risco de hipoglicemias agudas induzidas pelo exercício....(AU)

this current systematic review seeks evidence about the intermittent exercises practicing true effects on the glycemic response of people carrying type 1 diabetes. Methods: Researches were made on electronic databases: PubMed and Medline. The following descriptors were used in Portuguese and English: Intermittent exercises, interval exercises, intermittent high intensity and diabetes type 2166 articles were found with these previous descriptors, after an assortment process, there were 13 articles for full reading in which 06 articles was excluded, thus only 07 articles did fit in all the inclusion and exclusion criteria. The data survey was restricted to researching human beings of both genders in the last 10 years (2005-2015). Results: It was observed that 20-60 minutes practice of exercises with maximum intermittent sprints (about 4-30 sprints, 4-15 seconds duration), with interval periods of passive recovery or moderate intensity active recovery (40% and 50% VO²máx VO²pico), what can be expected is a glycemic decrease between 36 + 14.4mg/dl to 90 + 9 mg/dl and percentages from 18.18% to 54.05%. Conclusion: According to the studies analyzed, intermittent exercises favor a lower risk of acute hypoglycemia induced by exercises....(AU)